abstract:Objectives:(1) To assess the effects of a conventional, delayed physiotherapy protocol used by Ischemic Stroke (IS) and Hemorrhagic Stroke (HS) post-stroke patients, in their electromyographic activation patterns during hemiparetic gait; and (2) to study whether this protocol may improve the functional abilities in thi...
journal_title:Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liaopub_type: 杂志文章
doi:10.1142/S1013702521500074
更新日期:2021-12-01 00:00:00
abstract::Febuxostat (FXS) is a potent antigout drug with poor water solubility and relative high first-pass effect leading to moderate oral bioavailability (<49%). This study aimed to increase FXS solubility and bioavailability by optimizing sublingual fast-dissolving films (SFs) containing a selected FXS self-nano-emulsifying...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1927247
更新日期:2021-12-01 00:00:00
abstract::Combining two or more nanoparticles is a promising approach. Previously we have reported synthesis of nanoparticles Dysprosium (Dy) substituted with manganese (Mn) zinc (Zn) by using ultrasonication method. The five different nanoparticles (NPs) Mn0.5Zn0.5DyxFe2-xO4 (x ≤ 0.1) have been structurally and morphologically...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1938592
更新日期:2021-12-01 00:00:00
abstract::Cerebral ischemic stroke (CIS) is the most common type of stroke, which is highly hazardous. This investigation aims to analyze the correlation of miR-497 with CIS, so as to provide reliable evidence for clinical response to CIS and lay a solid foundation for follow-up research. Eighty-nine CIS patients and 39 concurr...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1940073
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Total Glucosides of Paeony (TGP) capsule possesses various hepatoprotective activities. No study is available concerning TGP's concentration-effect relationship on hepatoprotection. OBJECTIVE:To establish a pharmacokinetics-pharmacodynamics (PK-PD) modelling on TGP capsule's hepatoprotection after a single ora...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1937232
更新日期:2021-12-01 00:00:00
abstract::Migraine is a primary headache characterized by moderate or severe headache attacks, accompanied with reversible neurological and systemic symptoms. There are rare biomarkers for the disease. While emerging evidence has indicated the connection between gut microbiota and migraine, the relation between oral microbiota ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1933840
更新日期:2021-12-01 00:00:00
abstract:Background:The diagnosis of temporomandibular disorders (TMDs) is an important part of the functional cerebrospinal technique (FCST). In addition, surface electromyography (sEMG) is an important candidate for diagnosing TMD. In FCST, despite the importance of the cranio-cervical-mandibular system, few sEMG parameters c...
journal_title:Integrative medicine researchpub_type: 杂志文章
doi:10.1016/j.imr.2021.100732
更新日期:2021-12-01 00:00:00
abstract::Due to comprehensive social distancing measures related to the COVID-19 pandemic, medical faculties worldwide have made a virtue of necessity in resorting to online teaching. Medical faculties grapple with how to convey clinical competencies to students in this context. There is a need for research not only to map but...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2021.1940765
更新日期:2021-12-01 00:00:00
abstract::High production costs still hamper fast expansion of commercial production of polyhydroxyalkanoates (PHAs). This problem is greatly related to the cultivation medium which accounts for up to 50% of the whole process costs. The aim of this research work was to evaluate the potential of using volatile fatty acids (VFAs)...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1935524
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Ganoderma sinensis Zhao, Xu et Zhang (Ganodermataceae) has been used for the prevention or treatment of a variety of diseases, including cancer. OBJECTIVE:We investigated the antitumor activity and mechanism of an extract from G. sinensis against hepatocellular carcinoma. MATERIALS AND METHODS:A G. sinensis e...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1931354
更新日期:2021-12-01 00:00:00
abstract::The unclear pathogenesis mechanisms and resistance of cancer cells to chemical drugs serious limits the development of effective treatment strategies for non-small cell lung cancer (NSCLC). In this study, we managed to investigate this issue, and identify potential cancer associated biomarkers for NSCLC diagnosis, pro...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1936891
更新日期:2021-12-01 00:00:00
abstract::Septins, a conserved family of GTP-binding proteins, are widely recognized as an essential cytoskeletal component, playing important roles in a variety of biological processes, including division, polarity, and membrane remodeling, in different eukaryotes. Although the roles played by septins were identified in the mo...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1933370
更新日期:2021-12-01 00:00:00
abstract:AIMS:To evaluate risk factors for major adverse cardiac event (MACE) after the first acute coronary syndrome (ACS) and to examine the prevalence of risk factors in post-ACS patients. METHODS:We used Finnish population-based myocardial infarction register, FINAMI, data from years 1993-2011 to identify survivors of firs...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1924395
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Patients with chronic conditions pose a major challenge to the Danish healthcare system. Since 2018, disease management programmes for patients with chronic obstructive pulmonary disease (COPD) and type 2 diabetes (T2D) were introduced in Denmark. Treatment in hospitals should be reserved for those patients ...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1932810
更新日期:2021-12-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is a common malignant tumor, with high morbidity and mortality. Circular RNA (circRNA) circ_0003028 was reported to be upregulated in NSCLC. This study is designed to explore the role and mechanism of circ_0003028 on NSCLC progression. In this work, circ_0003028, microRNA-1298-5p (mi...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1935064
更新日期:2021-12-01 00:00:00
abstract::The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for novel, effective, and safer therapeutics. To this end, a series of 3,5-disubstituted-1,2,4-oxadiazole derivatives (3a-3i) were tested against H37...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1900162
更新日期:2021-12-01 00:00:00
abstract::Transformation of astrocytes into reactive states is considered one of the major pathological hallmarks of prion and other neurodegenerative diseases. Recent years witnessed a growing appreciation of the view that reactive astrocytes are intimately involved in chronic neurodegeneration; however, little is known about ...
journal_title:Prionpub_type: 杂志文章
doi:10.1080/19336896.2021.1930852
更新日期:2021-12-01 00:00:00
abstract::The long non-coding RNAs (lncRNAs) participate in modulating numerous important cancer phenotypes via formation of RNA-protein complex. TINCR (terminal differentiation-induced lncRNA) modulates cancer cell behavior in many human malignancies, such as hepatocellular carcinoma (HCC). Herein, we proposed to investigate t...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1930336
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Chronic myelogenous leukemia (CML) is one of the most common cancers in the world. Imatinib is one of the most effective therapeutic strategies to inhibit the BCR-ABL tyrosine Kinase in patients with CML, but resistance is increasingly encountered. MATERIAL AND METHODS:Microarray data GSE7114, GSE92624 and ...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1931740
更新日期:2021-12-01 00:00:00
abstract::Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of LPS has been related with reduced endotoxicity in several Gram-negat...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1929037
更新日期:2021-12-01 00:00:00
abstract::Choriocarcinoma (CC) is a gestational trophoblastic tumor secondary to a gravid or non-gravid pregnancy. It is characterized by rapid growth, high invasion, and high metastatic potential and chemotherapy resistance that significantly affect survival rate of CC patients. Insulin is implicated in alleviation of chemothe...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1931643
更新日期:2021-12-01 00:00:00
abstract::Long noncoding RNA (lnc RNA) is aberrant expressed in many kinds of tumors and may be concerned with the occurrence and progression of tumors. Lnc RNA MST1P2 is increased in cervical cancer (CC), but its mechanism in CC has not been clarified. In this study, RT-qPCR was employed to analyze Lnc MST1P2 and miR-133b expr...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1921550
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Processing with vinegar could enhance the efficacy and reduce the toxicity of Curcuma phaeocaulis Valeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities. OBJECTIVE:This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxici...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1874427
更新日期:2021-12-01 00:00:00
abstract::Several lineages of SARS-CoV-2 are currently circulating worldwide. During SARS-CoV-2 diagnostic activities performed in Abruzzo region (central Italy) several strains belonging to the B.1.177.75 lineage tested negative for the N gene but positive for the ORF1ab and S genes (+/+/- pattern) by the TaqPath COVID-19 CE-I...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1933609
更新日期:2021-12-01 00:00:00
abstract::Mammalian orthoreovirus (MRV) infects multiple mammalian species including humans. A United States Midwest swine farm with approximately one thousand 3-month-old pigs experienced an event, in which more than 300 pigs showed neurological signs, like "down and peddling", with approximately 40% mortality. A novel MRV was...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1933608
更新日期:2021-12-01 00:00:00
abstract::Phage-inspired antibacterial discovery is a new approach that recruits phages in search for antibacterials with new molecular targets, in that phages are the biological entities well adapted to hijack host bacterial physiology in favor of their own thrive. We previously observed that phage-mediated twitching motility ...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1926411
更新日期:2021-12-01 00:00:00
abstract::Myocardial injury resulting from sepsis is the leading cause of death worldwide. Micro RNA miR-122-5p is involved in various physiological and pathological processes and is highly expressed in the heart of septic rats. However, its function in sepsis-caused myocardial injury remains elusive. Herein, a rat model of sep...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1926201
更新日期:2021-12-01 00:00:00
abstract::The clear cell renal cell carcinoma (ccRCC) is the main pathological subtype of renal cell carcinoma. Immune system evasion, one hallmark of cancer, contributes to cancer cells in escaping from the attack of immune cells. In order to identify potential prognostic biomarkers in ccRCC patients and immune cells fraction,...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1924546
更新日期:2021-12-01 00:00:00
abstract::Coordinate system definition is a critical element of biomechanical modeling of the knee, and cases of skeletal trauma present major technical challenges. This paper presents a method to define a tibial coordinate system by fitting geometric primitives to surface anatomy requiring minimal user input. The method presen...
journal_title:International biomechanicspub_type: 杂志文章
doi:10.1080/23335432.2021.1916406
更新日期:2021-12-01 00:00:00
abstract::The designated hospitals are another health approach besides Fangcang shelter hospitals and newly built temporary hospitals for responding to COVID-19 epidemic in China. Faced with the emergency situation, about 1512 hospitals from 363 cities have been designated in China to tackle the spread of COVID-19. They were lo...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1931467
更新日期:2021-12-01 00:00:00
abstract::Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that poses significant threats to global public health. Macrophages and dendritic cells are both key sentinel cells in the host immune response and play critical roles in the pathogenesis of flavivirus infections. Recent studies showed that ZIKV could producti...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1929503
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:Treating red blood cells (RBCs) with dithiothreitol (DTT) is a wildly-recommended to overcome the interference of the daratumumab (DARA) with blood compatibility testing. Nevertheless, DTT can be hard to obtain in the clinical laboratory, while its use in routine practice may be time-consuming. In the follow...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1918916
更新日期:2021-12-01 00:00:00
abstract::In this paper, we compare and evaluate different testing protocols used for automatic COVID-19 diagnosis from X-Ray images in the recent literature. We show that similar results can be obtained using X-Ray images that do not contain most of the lungs. We are able to remove the lungs from the images by turning to black...
journal_title:An international journal on information fusionpub_type: 杂志文章
doi:10.1016/j.inffus.2021.04.008
更新日期:2021-12-01 00:00:00
abstract::The calcitonin gene-related peptide (CGRP) has been demonstrated relating to vascular and inflammatory regulations not only the nerve systems. As the anti-inflammation factor and the most potent vasodilator, the CGRP holds therapeutic potentials for the treatment of cardiovascular diseases which was, however, limited ...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1902021
更新日期:2021-12-01 00:00:00
abstract::Background: The opioid epidemic is a growing problem in the USA. Use of medication-assisted treatment (MAT) has been effective in treating patients with opioid use disorders (OUD) and maintaining sobriety; however, there is a significant shortage of physicians formally trained in MAT. Objective: Wayne State University...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2020.1847755
更新日期:2021-12-01 00:00:00
abstract::Universities worldwide are pausing in an attempt to contain COVID-19's spread. In February 2019, universities in China took the lead, cancelling all in-person classes and switching to virtual classrooms, with a wave of other institutes globally following suit. The shift to online platform poses serious challenges to m...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2020.1854066
更新日期:2021-12-01 00:00:00
abstract::Purpose: The purpose of this study was to examine how a novice teacher (researcher) has developed his assessment literacy in elementary physical education (PE), and thereby investigating what cultural, micropolitical and sociological factors have impacted on his enactment of assessment literacy. Method: Adopting autoe...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1882066
更新日期:2021-12-01 00:00:00
abstract::Purpose: Understanding the nature of wellbeing as multidimensional and complex provides a policy window to generate a strengths-based policy orientation to promote wellbeing in education settings. The purpose of this exploratory paper is to map how wellbeing is interpreted across public education policy documents in A...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1879370
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Machine learning (ML) algorithms have been widely used in the classification of white blood cells (WBCs). However, the performance of ML algorithms still needs to be addressed for being short of gold standard data sets, and even the implementation of the proposed algorithms. METHODS:In this study, the metho...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1879823
更新日期:2021-12-01 00:00:00
abstract::The founder of the Vienna School of Ophthalmology was Prof. Dr. Georg Joseph Beer, who founded the First University Eye Clinic in the Vienna General Hospital in 1812. Prof. Ferdinand von Arlt led it for 27 years from 1856 to 1883. As the First Eye Clinic became too small, the Second University Eye Clinic was founded i...
journal_title:Acta medico-historica adriatica : AMHApub_type: 传,历史文章,杂志文章
doi:10.31952/amha.18.2.7
更新日期:2021-12-01 00:00:00